From stem cell to T cell: one route or many?
نویسندگان
چکیده
منابع مشابه
From one cell to many
embryo undergoes several synchronized nuclear divisions without cytokinesis, to form a 'syncytial blastoderm'. During these divisions, the nuclei migrate to the cortex of the embryo where the last few divisions take place before cellularization. The dividing nuclei at lower right are all synchronized at metaphase. Mitotic spindles are stained red; DNA is stained green. At cellularization, the o...
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Objective Articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. On the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. Little is known about the presence of mesenchymal stem cells in articular cartilage tissue. This subject is investigated in the present study. Materials and Methods Artic...
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The thymus manufactures new T cells throughout life but contains no self-renewing potential. Instead, replenishment depends on recruitment of bone marrow-derived progenitors that circulate in the blood. Attempts to identify thymic-homing progenitors, and to assess the degree to which they are precommitted to the T cell lineage, have led to complex and sometimes conflicting results. As described...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2006
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1823